A separate 138 patients (26%), classified as ‘compromised,’ performed more than one s.d. below control means in all cognitive domains except estimated premorbid IQ and current visuospatial abilities. Patients classified as ‘deteriorated’ ( n=239, 44%) performed more than one s.d. of control means in all cognitive domains. Results:Ī total of 157 patients (29%) classified as ‘preserved’ performed within one s.d. Additional cognitive, functional, and symptom outcomes were compared among the resulting groups. Patients were classified into cognitive subgroups on the basis of the Wechsler Test of Adult Reading (a premorbid IQ estimate) and current overall cognitive abilities into preserved, deteriorated, and compromised groups using both clinical and empirical ( k-means clustering) methods. Methods:Ī total of 635 healthy controls and 534 patients with a diagnosis of schizophrenia or schizoaffective disorder were recruited through the Australian Schizophrenia Research Bank. In a relatively large, community cohort, we aimed to independently replicate and extend cognitive subtyping work by determining the extent of symptom severity and functional deficits in each group. Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelligence quotient (IQ) estimates.
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